Single-cell gene expression atlas of human pancreatic islets in health and type 2 diabetes
This page contains additional data supporting our resource reported in:
Single-cell transcriptome profiling of human pancreatic islets in health and type 2 diabetes
Åsa Segerstolpe*, Athanasia Palasantza*, Pernilla Eliasson, Eva-Marie Andersson, Ann-Christine Andreasson, Xiaoyan Sun, Simone Picelli, Alan Sabirsh, Magnus Bjursell, David M. Smith, Maria Kasper, Carina Ämmälä and Rickard Sandberg
Published in Cell Metabolism (2016)
Links to download the complete single-cell transcriptome resource as raw FastQ files in ENA
or processed expression data in ArrayExpress E-MTAB-5061
Search for an official gene name to explore its expression across the single-cell gene expression resource
Visualizing GCG expression across human pancreas:
summarising GCG expression levels across the 7 major cell types (shown in different colors) for every donor (shown in different shades of each color). The first 6 boxes correspond to healthy individuals (H1 to H6) and the last 4 to T2D individuals (T2D1 to T2D4). ε-cells were captured only in 5 donors (H2, H3, H6, T2D1, T2D4).
colored according to GCG expression levels of: (Left) all sequenced cells (n=2,209) or (Right) endocrine cells only (n=1,554). Compare with the corresponding t-SNE graphs/maps shown below (reproduced from Figure 1 of the paper).
Reproducing Figs 1B and 1E of Segerstolpe, Palasantza et al.
to show the placement of cell types onto the t-SNE maps.