Sandberg Lab
Ludwig Institute for Cancer Research & Department of Cell and Molecular Biology, Karolinska Institutet
welcome to sandberg lab
We are studying global aspects of gene regulation by combining genome-wide experimental and computational techniques to
better understand stem cell characteristics and differentiation processes. We aim towards a better understanding of the molecular regulation of gene expression programs by the combined study of gene regulation acting on different levels (e.g. transcriptional and post-transcriptional) using next-generation sequencing techniques. In particular, we are interested in gene expression regulation of differentiation and cell fates during mouse early embryonic development.Funded Postdoc Position Available!
News
An Abundance of Ubiquitously Expressed Genes Revealed by RNA-Seq
Using RNA-sequencing data from human and mouse tissues we explored general features of tissue transcriptomes. This work was done in collaboration with Burge lab (MIT) and is now out in PLoS Comp Biol. [Dec 2009]
ERC Starting Grant
The sandberg lab received a highly competitive Starting Grant from the European Research Council, therefore the lab will be expanding over the next few years. [Sep 2009]
RNA-seq of human tissue transcriptomes
Alternative mRNA regulation across human tissues and cell lines was investigated by illumina/solexa mRNA sequencing. This was a collaboration with Burge lab (MIT) and Schroth and co-workers at Illumina, Hayward. This work is now out in Nature. [Oct 2008]
3'UTR dynamics paper published in Science
The study on dynamical regulation of 3' untranslated regions is now published in Science (see publications). Python scripts for the probe level analysis and visualization will be maintained here. [Jun 2008]